Clostridioides difficile (C.diff) infection (CDI)

The National Institute for Health and Care Excellence (NICE) guideline on Clostridioides difficile infection: antimicrobial prescribing was published in July 2021. Scottish Antimicrobial Prescribing Group (SAPG) has reviewed the guidance and has made updated recommendations below. These antibiotic choice recommendations supersede those included in Scottish guidance on Clostridioides difficile infection (CDI)  published by the Scottish Health Protection Network (SHPN). Only antibiotic prescribing advice has been updated and the remainder of the guideline remains relevant to clinical practice and will be updated within the full guideline review.

Advice on antimicrobial management of Clostridioides difficile (C.diff) Infection (CDI) for adults (>18 years)

CDI decision tool

(Please see here for updated SAPG advice on CDI in children)

Content updated June 2024